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The cyclic peptide, Cycle [Pro-Tyr-Pro-Val], isolated from Swiss lactic acid bacteria, exhibited a tyrosinase IC50 of 1.5 mM, with inhibitory activity stronger than that of arbutin, which had an IC50 of 5.0 mM (Kawagishi et al., 1993) (Table 3)

After entering cells, AGF347 is catalyzed by folylpolyglutamate synthase (FPGS) to conjugate five glutamate residues, forming AGF347-Glu5

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To view a copy of this license, visit About this article Cite this article Ma, C., Gu, C., Lian, P

Front Pharmacol 13(March):18